(Left) Nerve cell and the Neuromuscular Junction (NMJ) where the neurotransmitter acetylcholine triggers a muscle contraction through the exchange of sodium (Na) and potassium (K) across muscle fibers. Voltage-gated potassium and calcium channels on the nerve cell regulate the amount of acetylcholine in the NMJ. The greater the calcium influx into the nerve cell, the more acetylcholine is available at the NMJ for muscle contraction. Exposure to botulism neurotoxins causes paralysis by blocking the release of acetylcholine from the nerve terminal. (Right) 3,4-DAPP blocks voltage-gated potassium channels, allowing calcium channels to remain open for a longer period and increasing the probability of releasing more acetylcholine. (DTRA JSTO image)
Date Taken: | 04.24.2024 |
Date Posted: | 04.24.2024 16:51 |
Photo ID: | 8360968 |
VIRIN: | 240424-D-D0490-1001 |
Resolution: | 2083x1385 |
Size: | 465.74 KB |
Location: | FT. BELVOIR, VIRGINIA, US |
Web Views: | 23 |
Downloads: | 1 |
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