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Malaria infections can be severe or even deadly, especially for those without preexisting immunity, such as travelers. Last year, 30 service members were infected with malaria while traveling to endemic areas, up 42 percent from 2021. The available preventive medication options, or malaria prophylaxis, help to keep cases low when combined with other preventive measures such as insect repellents and repellent-treated clothing.
Researchers from the Uniformed Services University of the Health Sciences (USU) Department of Pediatrics will soon be launching a study on how malaria drugs affect pregnant women and their unborn children.
According to USU assistant professor of Pediatrics Air Force Maj. (Dr.) Alison Helfrich, “Pregnant people are at higher risk for complications of malaria, including poor outcomes for both the mother and baby. Therefore, it is extremely important (for them) to be on prophylaxis while traveling to a malaria-endemic country.”
“We hope to specifically address the gap in safety evidence for malaria prophylaxis use during pregnancy and the outcomes for mothers and their infant,” says the study’s Principal Investigator and USU assistant professor of Pediatrics Dr. Elizabeth Lee.
Unrecognized pregnancies do happen in conjunction with deployment, albeit rare, according to Helfrich. She says women account for 17 percent of all active duty service members, 97 percent of whom are of reproductive age. So there is a chance these service members could be prescribed prophylaxis not currently approved for use in pregnancy.
“Unfortunately, because pregnant women aren’t routinely included in pre-marketing drug clinical trials, we do not know if the other available malaria medications are safe to use in pregnancy,” Helfrich says.
Lee adds the limited range of products available for women is a challenge for the military because, as the population of active-duty continues to include more women, more women of reproductive age will be deployed overseas for short- and long-term duty.
Lee says the team’s research will include identification of pregnancies through the Military Health System data repository, probable exposure to malaria prophylaxis including those approved and not approved for pregnancy, and associated outcomes for mothers and their infants.
The research builds on an existing USU Infectious Disease Clinical Research Program-supported study already looking at infectious disease outcomes for deployment and traveler health, including sexually transmitted infections, diarrhea and malaria. The researchers expect the malaria prophylaxis in pregnancy study to begin later this fall.
“We hope that our research may be able to expand the options of malaria prophylaxis medication for pregnant women,” says Helfrich. “Our findings have the potential to impact health and safety for active-duty service women and federal travelers, as well as short- and long-term travelers to malaria-endemic areas, and their families.”
| Date Taken: | 08.10.2023 |
| Date Posted: | 08.10.2023 13:46 |
| Story ID: | 451121 |
| Location: | MARYLAND, US |
| Web Views: | 55 |
| Downloads: | 0 |
This work, How do Malaria Drugs Affect Pregnancy? USU Researchers to Launch Study, by Ian Neligh, identified by DVIDS, must comply with the restrictions shown on https://www.dvidshub.net/about/copyright.
